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The role of specific CDPK isoforms in signal transduction of Arabidopsis thaliana

Reference	P15146
Principal Investigator / Supervisor	Professor Marc Knight
Co-Investigators / Co-Supervisors	Dr Joy Boyce
Institution	University of Oxford
Department	Plant Sciences
Funding type	Research
Value (£)	225,792
Status	Completed
Type	Research Grant
Start date	01/04/2001
End date	31/03/2004
Duration	36 months

Abstract

Different primary stimuli e.g. cold and drought provoke cytosolic calcium elevations that occur in different cells, have different kinetic characteristics and involve calcium from different cellular locations. Downstream of calcium, calcium-activated proteins must interpret this information and activate an appropriate response. Calcium-dependent protein kinases (CDPKs) are candidates for this mechanism, and circumstantial data implicates them in stress signalling in plants. However their involvement in specific signalling pathways have not been directly tested, nor has the possibility that different CDPKs may have different and distinct roles in plant signalling. We will measure the cell/tissue-specific and subcellular localisation of four different CDPK isoforms and relate these to the spatial characteristics of known calcium responses in order to gain information as to what specific signalling pathway they may be involved in. Also, by inhibiting the activity of specific CDPK isoforms we will determine the role and necessity of these isoforms in known calcium signalling pathways.

Summary

unavailable

Committee	Closed Committee - Plant & Microbial Sciences (PMS)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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