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Understanding the mode of action of the RPP1A and RPP1C proteins that confer downy mildew resistance in Arabidopsis
Reference
P15093
Principal Investigator / Supervisor
Professor Jonathan Jones
Co-Investigators /
Co-Supervisors
Institution
University of East Anglia
Department
Sainsbury Laboratory
Funding type
Research
Value (£)
203,188
Status
Completed
Type
Research Grant
Start date
08/01/2002
End date
07/03/2005
Duration
38 months
Abstract
Many plant disease resistance (R) genes encode nucleotide binding (NB), leucine rich repeat (LRR) domains, with an N terminal TIR domain. Little is known of how R proteins function. We will study two Arabidopsis TIR:NB:LRR proteins, RPP1A and RPP1C, that confer race-specific resistance to downy mildew. We will test the hypothesis that RPP1A and C guard host proteins targeted by the pathogen. Suppressor screens will identify genes specifically required for RPP1A function. Epitope tagged RPP1A and C proteins will be localized within the cell and used to identify interacting plant proteins using MALDI TOF mass spectrometry.
Summary
unavailable
Committee
Closed Committee - Plant & Microbial Sciences (PMS)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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