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Trans-cellular Ca2+ transport and Ca2+ homeostasis in calcifying microalgae
Reference
P15068
Principal Investigator / Supervisor
Professor Alison Taylor
Co-Investigators /
Co-Supervisors
Professor Colin Brownlee
Institution
Marine Biological Association
Department
The Laboratory
Funding type
Research
Value (£)
192,908
Status
Completed
Type
Research Grant
Start date
01/09/2001
End date
01/09/2004
Duration
36 months
Abstract
Calcifying marine coccolithophorid microalgae maintain exceptionally large sustained net trans-cellular Ca2+ fluxes from the external medium to the intracellular calcifying Golgi-derived compartment. How this is achieved while maintaining cytoplasmic Ca2+ homeostasis is presently unknown. These cells provide a unique model for the study of both calcium homeostasis and microscale biomineralisation. The proposed research will characterise the Ca2+ influx pathways at the plasma membrane and the responses of cytosolic Ca2+ to imposed Ca2+ influx plus determine the role of the capacitiative Ca2+ entry and the endoplasmic reticulum in trans-cellular Ca2+ transport by using a combination of electrophysiological, confocal imaging, microanalysis and biochemical approaches.
Summary
unavailable
Committee
Closed Committee - Plant & Microbial Sciences (PMS)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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