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Genetic manipulation of sesquiterpenoid lactones in lettuce
Reference
P15061
Principal Investigator / Supervisor
Professor John Mansfield
Co-Investigators /
Co-Supervisors
Institution
Imperial College London
Department
Biological Sciences
Funding type
Research
Value (£)
182,644
Status
Completed
Type
Research Grant
Start date
01/05/2001
End date
30/06/2004
Duration
38 months
Abstract
The sesquiterpene lactone (SL) profile in lettuce will be modified by sense and antisense expression of sesquiterpene cyclases. Altered profiles will be examined in transgenic cell suspensions and regenerated plants. The role of cyclases in the biosynthesis of guaianolide and germacranolide SLs including the phytoalexins lettucenin A and costunolide will be examined. The products of sesquiterpene cyclases cloned from lettuce will be determined and catalytic activity investigated using site-directed mutagenesis.
Summary
unavailable
Committee
Closed Committee - Plant & Microbial Sciences (PMS)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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