Award details

Turnover and inhibition of PEP carboxylase kinase

Reference	P15057
Principal Investigator / Supervisor	Professor Hugh Nimmo
Co-Investigators / Co-Supervisors	Professor Gareth Islwyn Jenkins
Institution	University of Glasgow
Department	IBLS Division of Biochemistry & Molecula
Funding type	Research
Value (£)	213,066
Status	Completed
Type	Research Grant
Start date	01/09/2001
End date	31/03/2006
Duration	55 months

Abstract

Phosphoenolpyruvate carboxylase (PEPc) kinase in the CAM plant Kalanchoe fedschenkoi is a unique member of the protein kinase superfamily. It comprises a kinase catalytic domain with no regulatory regions. It turns over very rapidly and is regulated (a) by synthesis/degradation and (b) by a newly- discovered inhibitor protein. The objectives of this grant are to define the mechanism responsible for the destruction of PEPc kinase protein, to test whether its rate of turnover is controlled by the circadian clock or other factors, to investigate the hypothesis that the kinase is turned over by the proteasome, and to characterise further the nature and control of the kinase inhibitor.

Summary

unavailable

Committee	Closed Committee - Plant & Microbial Sciences (PMS)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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