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Defining the pathways of iron acquisition in Helicobacter pylori

Reference	P14590
Principal Investigator / Supervisor	Professor Dave Kelly
Co-Investigators / Co-Supervisors	Professor Simon C Andrews
Institution	University of Sheffield
Department	Molecular Biology and Biotechnology
Funding type	Research
Value (£)	190,944
Status	Completed
Type	Research Grant
Start date	01/06/2001
End date	01/06/2004
Duration	36 months

Abstract

Helicobacter pylori is an ubiquitous human pathogen which colonises the gastric mucosa. We have recently show that one mechanism for iron acquisition in this bacterium is an ATP-driven ferrous iron transporter encoded by feoB, which can also mediate ferric iron uptake in concert with a ferric reductase system. In this proposal we will: (i) Identify components of the ferric reductase system (ii) Evaluate the role of the Fec and TonB-ExbBD systems in iron acquisition from ferric citrate, lactoferrin and transferrin, especially under Fe- limited conditions (iii) Investigate the molecular basis for the extreme nickel ion sensitivity of feoB mutant, (iv) Determine if low-affinity iron uptake is due to CorA mediated transport. The aim is to completely understand the pathways of iron transport in this important pathogen.

Summary

unavailable

Committee	Closed Committee - Plant & Microbial Sciences (PMS)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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