Award details

Metabolic engineering of Streptomyces for improved production of bioactive molecules

Reference	P14580
Principal Investigator / Supervisor	Professor Keith Chater
Co-Investigators / Co-Supervisors	Dr Mike Butler
Institution	John Innes Centre
Department	Molecular Microbiology
Funding type	Research
Value (£)	258,976
Status	Completed
Type	Research Grant
Start date	01/04/2001
End date	01/04/2004
Duration	36 months

Abstract

This project seeks to apply metabolic engineering to improve the production of bioactive compounds in model streptomyces that are used in industry as hosts for the production of novel metabolites. We have identified two distinct mechanisms for increasing antibiotic yield in fermentations of Streptomyces lividans. We wish to determine whether these alterations are additive when used in combination. The effects of these and other genetic modifications will be assessed using Metabolic Flux and Elementary Modes Analyses. Information derived from the Streptomyces coelicolor genome sequence and its functional analysis will identify additional targets for manipulation that should further enhance the efficiency of bioactive molecule production. (Joint with grant 90/MCT14582.)

Summary

unavailable

Committee	Closed Committee - Plant & Microbial Sciences (PMS)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

Associated awards:

P14582 Metabolic engineering of Streptomyces for improved production of bioactive molecules

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