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A functional analysis of genes encoding glucosyltransferases of sinapic acid: a major metabolite of the Brassicaceae

Reference	P14568
Principal Investigator / Supervisor	Professor Dianna Bowles
Co-Investigators / Co-Supervisors	Dr Joe Ross
Institution	University of York
Department	Biology
Funding type	Research
Value (£)	152,772
Status	Completed
Type	Research Grant
Start date	23/11/2001
End date	23/11/2004
Duration	36 months

Abstract

We have identified a closely related group of 4 genes in Arabidopsis encoding UDP glucosyltransferases (UGTs) capable of forming the glucose ester of sinapic acid, sinapoylglucose. This ester is the terminal intermediate in the formation of sinapoylmalate, potentially a UV protectant and sinapoylcholine (sinapine), produced during seed development as a storage metabolite. Transgenic Arabidopsis overexpressing the UGTs are available as well as knockout lines for 3 of the 4 genes. The aim of the study is to undertake a functional analysis of the 4 genes in relation to sinapate metabolism in the plant. This will involve expression analyses and metabolite profiling which in turn will provide the basis for evaluating sinapoylmalate and other phenylpropanoid metabolites in resistance to UV damage as well as the basis for designing novel methods of reducing sinapine in oilseeds.

Summary

unavailable

Committee	Closed Committee - Plant & Microbial Sciences (PMS)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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