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14-3-3 protein function in plants
Reference
P14567
Principal Investigator / Supervisor
Dr Michael Roberts
Co-Investigators /
Co-Supervisors
Institution
Lancaster University
Department
Biological Sciences
Funding type
Research
Value (£)
172,848
Status
Completed
Type
Research Grant
Start date
13/08/2001
End date
13/08/2004
Duration
36 months
Abstract
14-3-3 proteins regulate the activities of many enzyme and signalling proteins in eukaryotic cells via direct protein-protein interactions. Whilst many 14-3-3-interacting proteins from plants have been identified, the roles which 14-3-3 proteins play in regulating different aspects of plant biology have been difficult to address because of genetic redundancy. To begin to examine these roles, we plan to develop a generic system to inhibit 14-3-3 function in transgenic plant tissues. The basis of this system will be the over- expression of a peptide antagonist which competes with endogenous proteins for 14-3-3 binding. The system will be tested and optimised using assays of known 14-3-3 target protein activities and then applied to investigate 14-3-3 function during a plant pathogen resistance response.
Summary
unavailable
Committee
Closed Committee - Plant & Microbial Sciences (PMS)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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