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Directionality of solute movement by ABC transporters
Reference
P14564
Principal Investigator / Supervisor
Professor Philip Poole
Co-Investigators /
Co-Supervisors
Institution
University of Reading
Department
Animal and Microbial Sciences
Funding type
Research
Value (£)
188,900
Status
Completed
Type
Research Grant
Start date
01/01/2001
End date
01/01/2004
Duration
36 months
Abstract
ABC transport systems constitute one of the largest and most important families for solute movement. Among the best studied model systems for this family are the bacterial uptake systems. These have the same core domain structure as all other ABC systems but in addition have a periplasmic binding protein (PBP). We have proposed that these systems are bi-directional rather than being strictly undirectional which is the accepted model. Our work shows that 3 different bacterial ABC uptake systems will allow solute movement in both directions with the Vmax for uptake and export being very similar. The main difference is a 10,000- 100,000 fold higher affinity for uptake versus export. This difference may be determined by the PBP. We propose to investigate the role of the PBP and the mechanism of solute uptake and export by bacterial ABC transporters.
Summary
unavailable
Committee
Closed Committee - Plant & Microbial Sciences (PMS)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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