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A functional analysis of DNA ligases from Arabidopsis thaliana
Reference
P14460
Principal Investigator / Supervisor
Dr Clifford Bray
Co-Investigators /
Co-Supervisors
Dr Christopher West
Institution
The University of Manchester
Department
Life Sciences
Funding type
Research
Value (£)
239,688
Status
Completed
Type
Research Grant
Start date
01/07/2001
End date
31/12/2004
Duration
42 months
Abstract
DNA ligases play crucial roles in DNA replication, excision repair and genetic recombination but our knowledge of these enzymes in plant systems is rudimentary. Recently we have cloned three distinct Arabidopsis DNA ligases including a novel DNA ligase unique to higher plants. We will employ a combined biochemical and molecular genetic approach to (i) dissect post transcriptional control mechanisms which determine DNA ligase I isoform expression in Arabidopsis, (ii) investigate the targeting of DNA ligases to intracellular sites of action and (iii) elucidate the role(s) of each DNA ligase in DNA metabolism.
Summary
unavailable
Committee
Closed Committee - Plant & Microbial Sciences (PMS)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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