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Characterisation of the Gram-negative bacterial autotransporter secretion mechanism
Reference
P14130
Principal Investigator / Supervisor
Professor Ian Henderson
Co-Investigators /
Co-Supervisors
Institution
University of Birmingham
Department
Medical Sciences - Medicine
Funding type
Research
Value (£)
204,001
Status
Completed
Type
Research Grant
Start date
23/04/2001
End date
08/09/2004
Duration
40 months
Abstract
Many Gram-negative pathogens export proteins via the autotransporter secretion mechanism. In many ways this is the least understood of the bacterial export pathways. This extremely efficient mechanism may be the predominant means of export for organisms such at the Bordetella spp and Helicobacter pylori and is also common among the Enterobacteriaceae. This proposal outlines a research program designed to elucidate all aspects of autotransporter secretion: inner membrane, periplasmic and outer membrane translocation. The research will utilise our candidate autotransporter, Pet, a toxin of Escherichia coli and we will then extend our observations to other autotransporters. This research will result in general contributions to bacterial pathogenesis and will provide the information to determine if autotransporters offer potential as antigen delivery vehicles.
Summary
unavailable
Committee
Closed Committee - Plant & Microbial Sciences (PMS)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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