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Quinones and quinone reductase: roles in resisting oxidative and nitrosative stress in Escherichia coli
Reference
P14087
Principal Investigator / Supervisor
Professor Robert K Poole
Co-Investigators /
Co-Supervisors
Professor Britta Sobelle
Institution
University of Sheffield
Department
Molecular Biology and Biotechnology
Funding type
Research
Value (£)
206,004
Status
Completed
Type
Research Grant
Start date
30/09/2001
End date
30/09/2004
Duration
36 months
Abstract
Quinones are essential components of biological, electron transfer chains but also play key antioxidant roles in microbial, plant and animal cells. Using Escherichia coli as a model system, we aim to: 1) understand the basis of protection by quinones from oxidative stress and from nitric oxide (NO), and related reactive species (i.e. nitrosative stress); and 2) determine the function of quinone oxidoreductase (Qor), in particular explaining its presumed role in quinone reduction, oxygen consumption protection from oxidative and nitrosative stresses.
Summary
unavailable
Committee
Closed Committee - Plant & Microbial Sciences (PMS)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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