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Characterisation of a novel P-type ATPase gene involved in pathogenicity of the rice blast fungus Magnaporthe grisea
Reference
P14077
Principal Investigator / Supervisor
Professor Nicholas Talbot
Co-Investigators /
Co-Supervisors
Institution
University of Exeter
Department
Biosciences
Funding type
Research
Value (£)
212,588
Status
Completed
Type
Research Grant
Start date
01/10/2000
End date
01/10/2003
Duration
36 months
Abstract
The PDE1 gene from M. grisea was identified by insertional mutagenesis as a pathogenicity mutant producing non-functional appressoria. Pde1 mutants do not penetrate plant cuticles effectively, or form infection hyphae. PDE1 appears to encode a novel P-type ATPase which forms a new group of these membrane proteins. This project aims to characterise PDE1 to determine its function in plant infection. The functional relatedness of PDE1 with the closely related yeast P- ATPase gene ATC8 will first be determined. Regulation of PDE1 expression will also be analysed in relation to the cAMP/MAP kinase signalling pathway that controls appressorium function in M. grisea. Finally, the functional conservation of PDE1 in the cereal pathogens Mycosphaerella graminicola and Blumeria graminis will be studied in order to test the potential of PDE1 as a target for disease control of cereal pathogens.
Summary
unavailable
Committee
Closed Committee - Plant & Microbial Sciences (PMS)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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