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Coordination of nitrate and nitrogen metabolite signalling at the level of transcript stability

Reference	P14059
Principal Investigator / Supervisor	Professor Mark Caddick
Co-Investigators / Co-Supervisors	Dr Meriel Jones
Institution	University of Liverpool
Department	Sch of Biological Sciences
Funding type	Research
Value (£)	236,836
Status	Completed
Type	Research Grant
Start date	09/04/2001
End date	09/04/2004
Duration	36 months

Abstract

We aim to develop a detailed understanding of the mechanisms by which nitrogen metabolite and nitrate signalling act, and how they are co-ordinated, at the level of transcript stability in the fungus Aspergillus nidulans. This work will utilise molecular genetic techniques to focus primarily on two genes, the major regulatory gene areA and the structural gene for nitrate reductase, niaD. The work aims to provide a clear insight into a fundamental level of gene regulation, which combines with transcriptional and post-translational mechanisms to modulate nitrogen metabolism appropriately. This model system is likely to reveal important principals of gene regulation whilst also being of direct relevance to organisms.

Summary

unavailable

Committee	Closed Committee - Plant & Microbial Sciences (PMS)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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