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The role of peptide-N-glycanases and N-glycans in plant development
Reference
P13891
Principal Investigator / Supervisor
Dr Michael Roberts
Co-Investigators /
Co-Supervisors
Dr David Ashford
,
Professor Dianna Bowles
Institution
Lancaster University
Department
Biological Sciences
Funding type
Research
Value (£)
211,980
Status
Completed
Type
Research Grant
Start date
01/08/2001
End date
01/08/2004
Duration
36 months
Abstract
We have previously characterised a novel peptide: N-glycanase (PNGase) activity which is developmentally regulated during fruit ripening in tomato. Work in other laboratories has also indicated that free N-glycans, the products of PNGase activity, may be important signalling molecules in plants. We have now identified genes encoding PNGase enzymes in both Arabidopsis and tomato, opening the way for a detailed investigation of the role of PNGases and their products in plant biology. We aim to use over-expression and co-suppression approaches to study the role of PNGase enzyme activity and free N-glycan levels during fruit development in tomato, and to employ functional genomics to investigate broader roles for PNGase activity in Arabidopsis. Finally, we will assess the biochemical properties of recombinant PNGase enzymes.
Summary
unavailable
Committee
Closed Committee - Plant & Microbial Sciences (PMS)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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