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Characterisation of the protein encoded by the Arabidopsis powdery mildew disease resistance gene RPW8.2

Reference	P13843
Principal Investigator / Supervisor	Dr Mark John Coleman
Co-Investigators / Co-Supervisors	Professor John Turner
Institution	University of East Anglia
Department	Biological Sciences
Funding type	Research
Value (£)	200,168
Status	Completed
Type	Research Grant
Start date	31/03/2001
End date	30/09/2004
Duration	42 months

Abstract

We have recently isolated the Arabidopsis RPW8 locus, which confers broad- spectrum resistance to powdery mildew fungi. The locus contains two functional genes (RPW8.1 and RPW8.2) and these encode novel protein products, unrelated to the products of other plant disease resistance genes and not closely related to any other characterised proteins. To further our understanding of RPW8-mediated resistance, we will perform experiments to identify the cellular and sub- cellular location of RPW8.2 and to determine if the protein is degraded, accumulates, or relocates during the defence response. We will also perform a structure-function analysis by assessing natural variation in primary structure and resistance conferring ability, and by designing, constructing and testing mutants.

Summary

unavailable

Committee	Closed Committee - Plant & Microbial Sciences (PMS)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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