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The expression and function of matrix metalloproteinase homologues in Arabidopsis thaliana
Reference
P13785
Principal Investigator / Supervisor
Professor Ian Clark
Co-Investigators /
Co-Supervisors
Dr Maureen McCann
,
Professor Gillian Murphy
Institution
University of East Anglia
Department
Biological Sciences
Funding type
Research
Value (£)
200,288
Status
Completed
Type
Research Grant
Start date
01/01/2001
End date
31/08/2004
Duration
44 months
Abstract
The matrix metalloproteinases (MMPs), a family of at least twenty proteinases in vertebrates, can degrade many extracellular matrix (ECM) macromolecules and are important in physiology and pathology. We have identified five sequences in the Arabidopsis database which encode protein products homologous to MMPs. Plant ECM has a central role in plant growth, development and interaction with the environment. Remodelling of this ECM, which contains 2-10 percent protein, is critical to these processes. We have gathered strong preliminary data on the expression and biochemistry of these Arabidopsis thaliana MMPs. The current application brings together world-renowned expertise in MMPs (UEA) and plant ECM and Arabidopsis biology (John Innes Centre) to explore their expression and function in the plant.
Summary
unavailable
Committee
Closed Committee - Plant & Microbial Sciences (PMS)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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