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Gene switches in Erysiphe graminis: from descriptive to predictive biology in obligate biotrophs

Reference	P13735
Principal Investigator / Supervisor	Professor Pietro Spanu
Co-Investigators / Co-Supervisors	Professor Ian Moore
Institution	Imperial College London
Department	Biological Sciences
Funding type	Research
Value (£)	122,996
Status	Completed
Type	Research Grant
Start date	01/11/2000
End date	01/11/2002
Duration	24 months

Abstract

To define the function of genes possibly involved in development and pathogenicity in an obligate biotroph, tools for the conditional suppression of gene expression are an absolute requirement. We aim at developing these tools for Erysiphe graminis f.sp. hordei (Egh), the causal agent of barley powdery mildew. A number of systems for the conditional induction and repression of transgenes will be tested based on: 1) the alc regulon of Aspergillus; 2) chimaeric multicomponent steroid-inducible systems; and 3) chimaeric steroid repressible systems. In addition, down-regulation of gene expression in Egh will be tested using antisense technology. Part of the work will also aim at obtaining gene replacement using homologous recombination.

Summary

unavailable

Committee	Closed Committee - Plant & Microbial Sciences (PMS)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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