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Analysis of disease resistance signalling protein interactions in plant cells
Reference
P13714
Principal Investigator / Supervisor
Professor Sir David Baulcombe
Co-Investigators /
Co-Supervisors
Dr Bart Feys
Institution
University of East Anglia
Department
Sainsbury Laboratory
Funding type
Research
Value (£)
246,436
Status
Completed
Type
Research Grant
Start date
01/09/2000
End date
01/09/2003
Duration
36 months
Abstract
Genetic analysis and molecular cloning in the model plant, Arabidopsis, have led to the isolation and structural characterisation of two disease resistance signalling genes, EDS1 and PAD4. Both encode lipase-like proteins that interact specifically in a yeast two-hybrid assay. In the plant they are genetically linked in the same pathway, operating upstream of salicylic acid-mediated defences. The aim of this project is to examine the expression, localisation, and interactions of the EDS1 and PAD4 proteins in healthy and pathogen- challenged plant cells. The molecular tools developed in this analysis will also be used to isolate and signature further interacting components of this pathway using proteomic technologies.
Summary
unavailable
Committee
Closed Committee - Plant & Microbial Sciences (PMS)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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