Award details

Assembly of infectious bluetongue virion from cDNA clone

Reference	P13500
Principal Investigator / Supervisor	Professor Polly Roy
Co-Investigators / Co-Supervisors
Institution	London Sch of Hygiene and Trop Medicine
Department	Infectious and Tropical Diseases
Funding type	Research
Value (£)	322,962
Status	Completed
Type	Research Grant
Start date	01/08/2000
End date	01/04/2004
Duration	44 months

Abstract

Members of the Reoviridae family consist of 10-12 discrete segments of double- stranded (ds) RNA genome, encapsidated by multi-layered protein components. The precise packaging of each RNA segment within each particle is a key step in the virus replication cycle and subsequent generation of infectious virions. Very little advance has been made to date in understanding the replication processes of these viruses due to the lack of a suitable system which allows genetic manipulation. This proposal concerns the establishment of such systems (reverse genetics that is, infectious cDNA clone) for a dsRNA virus, in particular, bluetongue virus (BTV), for which much is known, both at the structural and molecular genetic levels. This will be achieved by taking advantage of the extensive reagents and assay systems that are available in this laboratory, and by exploiting the versatile replication capabilities of BTV.

Summary

unavailable

Committee	Closed Committee - Plant & Microbial Sciences (PMS)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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