Award details

The role of calcium in ozone-GST signal transduction

Reference	P13334
Principal Investigator / Supervisor	Professor Alistair Hetherington
Co-Investigators / Co-Supervisors	Professor Marc Knight, Dr Martin Mcainsh
Institution	Lancaster University
Department	Lancaster Environment Centre
Funding type	Research
Value (£)	177,580
Status	Completed
Type	Research Grant
Start date	06/11/2000
End date	06/11/2003
Duration	36 months

Abstract

The objective of the work is to investigate the role of cytosolic free calcium ions ([Ca2+]cyt) in the signal transduction pathway linking ozone perception to increases in the expression of the defence gene glutathione-S-transferase (GST). Specifically it is our intention to obtain answers to the following questions: 1) in which tissues does ozone induce an increase in [Ca2+]cyt?; 2) in which cells does ozone induce an increase in [Ca2+]cyt?; 3) in which cells does ozone induce an increase in GST expression? Does this pattern mirror the pattern of cells that respond to ozone with an increase in [Ca2+]cyt?; and 4) what is the relationship between the increases in [Ca2+]cyt and salicylic acid in the ozone-[Ca2+]cyt-GST signal transduction pathway?

Summary

unavailable

Committee	Closed Committee - Plant & Microbial Sciences (PMS)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

I accept the terms and conditions of use (opens in new window)

export PDF file

back to list new search