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ASY: a gene required for the synaptonemal complex assembly in Arabidopsis
Reference
P13244
Principal Investigator / Supervisor
Professor Chris Franklin
Co-Investigators /
Co-Supervisors
Dr G Jones
Institution
University of Birmingham
Department
Sch of Biosciences
Funding type
Research
Value (£)
196,460
Status
Completed
Type
Research Grant
Start date
01/10/2000
End date
01/10/2003
Duration
36 months
Abstract
We propose to carry out a detailed molecular and cytological study of Arabidopsis meiotic genes of special interest (ASY1/2) which when mutated result in failure of meiotic chromosome synapsis. Our evidence indicates that ASY1/2 are Arabidopsis homologues of the HOP1 gene from yeast that (in yeast) encodes a synaptonemal complex component. The distribution of the Asy1 and Asy 2 proteins will be explored using immunolocalisation and bioimaging. A comparative study of ASY1 and ASY2 will be initiated to determine their contribution to chromosome synapsis. The Asy1/2 proteins will be used to identify interacting proteins that also participate in the synaptonemal complex assembly and function.
Summary
unavailable
Committee
Closed Committee - Plant & Microbial Sciences (PMS)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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