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The complete genome expression profile of a baculovirus
Reference
P13230
Principal Investigator / Supervisor
Professor Pietro Spanu
Co-Investigators /
Co-Supervisors
Institution
Imperial College London
Department
Biological Sciences
Funding type
Research
Value (£)
173,800
Status
Completed
Type
Research Grant
Start date
01/12/2000
End date
19/05/2004
Duration
41 months
Abstract
DNA arrays will be generated that include all the predicted genes of the baculovirus Autographa californica nucleopolyhedrovirus (AcMNPV). These will be used to simultaneously monitor the expression of all AcMNPV genes throughout the infection cycle. The data obtained will be validated by comparison to Northern blot data for selected genes. AcMNPV mutants lacking a functional ie2, lef7, 39k or pcna gene will be generated. The effect of the disruption of each of these genes on global gene expression profiles during infection will be determined.
Summary
unavailable
Committee
Closed Committee - Plant & Microbial Sciences (PMS)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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