Award details

Functions and assembly of cytochrome bd a versatile bacterial oxidase

Reference	P12980
Principal Investigator / Supervisor	Professor Robert K Poole
Co-Investigators / Co-Supervisors
Institution	University of Sheffield
Department	Molecular Biology and Biotechnology
Funding type	Research
Value (£)	177,236
Status	Completed
Type	Research Grant
Start date	16/10/2000
End date	15/11/2003
Duration	37 months

Abstract

Cytochrome bd is a bacterial terminal quinol oxidase of unique structure and composition. In addition to its function as oxygen reductant, cytochrome bd is involved in resisting iron deprivation, oxidative stress, stationary phase survival and pathogenicity. This project aims to understand why cytochrome bd, but not the alternative oxidase, cytochrome bo, is required for responses to environmental stresses. Attention will be focused on interaction of the oxidase with periplasmic redox processes and its possible roles in NA+-motive respiration at high pH. In addition, the function of the CydDC ABC-type transporter, required not only for assembly of cytochrome bd, but also of periplasmic cytochromes, will be probed.

Summary

unavailable

Committee	Closed Committee - Plant & Microbial Sciences (PMS)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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