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Roles of multiple `TRAP' transporters in the physiology of Rhodobacter capsulatus and Pseudomonas aeruginosa
Reference
P12748
Principal Investigator / Supervisor
Professor Dave Kelly
Co-Investigators /
Co-Supervisors
Institution
University of Sheffield
Department
Molecular Biology and Biotechnology
Funding type
Research
Value (£)
210,544
Status
Completed
Type
Research Grant
Start date
23/10/2000
End date
22/12/2003
Duration
38 months
Abstract
In previous BBSRC funded work, we identified a new type of three- component solute transporter which is periplasmic binding-protein dependent but driven by the proton-motive force and not ATP hydrolysis. We have designated these new systems TRAP (Tripartite ATP-independent Periplasmic) transporters. At present the only TRAP system which has been both sequenced and functionally characterised is the C4-dicarboxylate transport (Dct) system from of Rhodobacter capsulatus. However genomics has shown that TRAP transporters are widespread in prokaryotes, but their functional diversity has yet to be explored. Here, we propose to: (1) Determine the function of three different types of TRAP transporter in R. capsulatus, which are present in addition to the Dct system and which show structural features distinct from it; and (2) Investigate three similar types of TRAP transporter in Pseudomonas aeruginosa which all show high similarity to the Dct system in R. capsulatus and which we believe are physiologically distinct C4- dicarboxylate transporters, but with unknown individual roles. The work proposed in both of these bacteria will significantly increase our knowledge of the biology of TRAP transporters.
Summary
unavailable
Committee
Closed Committee - Plant & Microbial Sciences (PMS)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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