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Control of fimbriation in E. coli in response to alanine leucine and nitrogen stress
Reference
P12206
Principal Investigator / Supervisor
Dr Ian Blomfield
Co-Investigators /
Co-Supervisors
Institution
University of Kent
Department
Sch of Biosciences
Funding type
Research
Value (£)
185,664
Status
Completed
Type
Research Grant
Start date
01/08/2000
End date
31/07/2003
Duration
36 months
Abstract
Fimbriation is a substantial drain on the amino acid pool. Preliminary studies show that the phase variation of type 1 fimbriation in E. coli is stimulated by alanine and leucine, and that this regulation involves a change in the interaction of a regulatory protein (Lrp) with fim DNA. We plan to determine (i) how the amino acids affect Lrp to stimulate the site-specific recombination that causes phase variation (ii) why alternative Lrp-fim nucleoprotein structures affect switching so differently and (iii) the affect of nitrogen stress on fimbriation. This regulation appears to be a key control point for amino acid consumption and this study should illustrate how an important cellular structure is controlled in response to nutritional stress.
Summary
unavailable
Committee
Closed Committee - Plant & Microbial Sciences (PMS)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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