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Cohesin function during meiosis in Arabidopsis
Reference
P12013
Principal Investigator / Supervisor
Professor Hugh Dickinson
Co-Investigators /
Co-Supervisors
Dr Anuj Bhatt
Institution
University of Oxford
Department
Plant Sciences
Funding type
Research
Value (£)
206,336
Status
Completed
Type
Research Grant
Start date
01/01/2000
End date
31/12/2002
Duration
36 months
Abstract
The DIF1 gene of Arabidopsis shows homology to cohesins, conserved proteins implicated in DNA repair, sister chromatoid cohesion and meiotic recombination. DIF1, uniquely, amongst all multi-cellular eukaryotes is the only gene with a mutant phenotype described to date, which has an ascribed role in meiotic recombination. We have also cloned and sequenced, a second cohesin gene from Arabidopsis, AtRAD21, a homologue of the DIF1 gene whose function will be analysed. The vital role cohesins play during early stages of meiosis will be studied using Arabidopsis mutants for each of the cohesin genes -DIF1 and AtRAF2. The function(s) of Arabidopsis cohesins during the critical stages of recombination, chromosome segregation and sister chromatid cohesion during meiosis will be addressed using molecular, genetic and imaging techniques.
Summary
unavailable
Committee
Closed Committee - Plant & Microbial Sciences (PMS)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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