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Characterisation of fission yeast Tup Ssn6 proteins and their role in the regulation of stress inducible genes
Reference
P11981
Principal Investigator / Supervisor
Dr Simon Whitehall
Co-Investigators /
Co-Supervisors
Institution
Newcastle University
Department
School of Cell and Molecular Biosciences
Funding type
Research
Value (£)
188,431
Status
Completed
Type
Research Grant
Start date
01/01/2000
End date
01/01/2003
Duration
36 months
Abstract
Schizosaccharomyces pombe is an ideal model organism for the study of the eukaryotic stress response. Evidence suggests that newly identified S. pombe homologues of the budding yeast repressor proteins, Tup1 and Ssn6, are involved in this process. Deletion of the S. pombe tup 1 gene increases resistance to various environmental stresses and influences the expression of several genes that are controlled by the Sty1 kinase. The functions of the other proteins, Tup2 and Ssn6 remain to be determined. The aim of this work is to: 1) Investigate the interactions of the Tup and Ssn6 proteins 2) Define their roles in the regulation of stress genes. 3) Determine their interactions with components of the Sty1 MAP kinase pathway.
Summary
unavailable
Committee
Closed Committee - Plant & Microbial Sciences (PMS)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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