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Targets and functions of inositol hexakisphophate action in plants

Reference	P11978
Principal Investigator / Supervisor	Professor Charles Brearley
Co-Investigators / Co-Supervisors	Dr Fouad Lemtiri-Chlieh, Professor Alex Webb
Institution	University of East Anglia
Department	University of East Anglia Department
Funding type	Research
Value (£)	215,457
Status	Completed
Type	Research Grant
Start date	15/09/1999
End date	01/05/2004
Duration	56 months

Abstract

Our new data demonstrates that the plant stress hormone abscisic acid (ABA) activates myo- inositol hexakisphosphate (InsP6) metabolism in stomatal guard cells and that InsP6 can regulate guard cell plasma membrane potassium channels (Ik,in) in a calcium- dependent manner. It is likely therefore that we have identified a physiological role for InsP6 in the osmoregulatory responses of higher eukaryotes. Within the context of ABA- signalling in guard cells we will use electro-physiological techniques combined with fluorescence ratio photometry measurement of free internal calcium to identify how InsP6 and cytosolic free calcium interact to regulate Ik,in. Transgenic plants which show altered InsP6 metabolism will help us define in planta the contribution of inositol phosphates to ion channel control and guard cell physiology. We will similarly investigate whether InsP6 regulates ion channels other than Ik,in and whether this regulation is also ABA- or calcium-dependent. This will define the specific contribution of InsP6 to ABA signalling pathways and perhaps more broadly to the osmoregulatory signalling processes of higher eukaryotes.

Summary

unavailable

Committee	Closed Committee - Plant & Microbial Sciences (PMS)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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