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Structure-function studies of the plant alternative oxidase by site-directed mutagenesis
Reference
P11956
Principal Investigator / Supervisor
Professor Anthony Moore
Co-Investigators /
Co-Supervisors
Dr Mary Albury
Institution
University of Sussex
Department
Sch of Life Sciences
Funding type
Research
Value (£)
195,319
Status
Completed
Type
Research Grant
Start date
01/10/1999
End date
01/10/2002
Duration
36 months
Abstract
The objective of the present proposal is to be use the heterologous S. pombe alternative oxidase expression system to further investigate the structure of the alternative oxidase by site- directed mutagenesis experiments. The goal of these studies will be: 1) to investigate the active-site by mutating the residues postulated to act as ligands, 2) to investigate the function of the highly conserved surface-located helix, 3) to probe the nature of the quinone binding site and 4) to further characterise the quinone binding site using new alternative oxidase inhibitors.
Summary
unavailable
Committee
Closed Committee - Plant & Microbial Sciences (PMS)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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