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Signal recognition gene regulation and transport control by a PAS-domain-containing two-component sensor
Reference
P11941
Principal Investigator / Supervisor
Professor Simon C Andrews
Co-Investigators /
Co-Supervisors
Professor Dave Kelly
Institution
University of Reading
Department
Animal and Microbial Sciences
Funding type
Research
Value (£)
172,052
Status
Completed
Type
Research Grant
Start date
15/11/1999
End date
22/02/2003
Duration
39 months
Abstract
PAS domains function as sensory modules in prokaryotic proteins, such as NifL, FixL, Aer and ArcB, involved in gene regulation. approx. 200 PAS domain sequences from prokaryotes are in the databases, indicating an important but largely untested role for PAS domains in prokaryotic responses to the environment. The newly discovered DcuSR two- component response-regulator of E. coli contains two input domains on the DcuS protein: an N-terminal periplasmic sensor of C4-dicarboxylates and a central PAS domain likely to function in redox sensing. Such a structural organisation is common for prokaryotic PAS proteins, indicating that DcuS would be a highly relevant (as well as tractable) model. We propose to build on our previous work by investigating the specific functions of the DcuS input domains. We will also study the apparent interaction and mutual regulation of the DcuS and DctA (C4- dicarboxylate transporter) proteins.
Summary
unavailable
Committee
Closed Committee - Plant & Microbial Sciences (PMS)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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