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Molecular genetic dissection of the RPP5-mediated disease resistance pathway in Arabidopsis
Reference
P11874
Principal Investigator / Supervisor
Professor Sir David Baulcombe
Co-Investigators /
Co-Supervisors
Institution
University of East Anglia
Department
Sainsbury Laboratory
Funding type
Research
Value (£)
201,465
Status
Completed
Type
Research Grant
Start date
01/02/2000
End date
01/02/2003
Duration
36 months
Abstract
Genetical analysis of the model plant Arabidopsis has established the existence of two disease resistance signalling pathways conditioned by particular Resistance (R) gene structural classes. The cloned R genes RPP5, RPP1, recognising an oomycete pathogen, and RPS4, a bacterial pathogen, are representatives of a major R gene class that requires the signalling gene, EDS1. Mutational screens revealed two further unique genes, RTR1 and RTR2, that are essential for RPP5/EDS1-mediated defence. The project aims to positionally clone RTR1 and RTR2 and examine their structure, function and expression. Their genetic and molecular interaction with RPP5, EDS1 and another regulatory component of this pathway, PAD4, will also be determined.
Summary
unavailable
Committee
Closed Committee - Plant & Microbial Sciences (PMS)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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