Award details

Calcium channels and calcium signalling in the filamentous fungus Aspergillus nidulans

Reference	P11711
Principal Investigator / Supervisor	Professor Dale Sanders
Co-Investigators / Co-Supervisors	Professor Nick Read
Institution	University of York
Department	Biology
Funding type	Research
Value (£)	172,153
Status	Completed
Type	Research Grant
Start date	01/07/1999
End date	01/07/2002
Duration	36 months

Abstract

Calcium signalling plays a key role in many aspects of fungal development, including tip growth in filamentous fungi. However, the pathways by which Ca2+ crosses the plasma membrane remain to be identified at a molecular level. We have recently demonstrated that the CCH1/MID1 genes of yeast are jointly involved in signalling-related Ca2+ entry, and have now identified homologs of these genes in Aspergillus nidulans. We will (i) obtain full- length clones of these genes; (ii) construct deletion and overexpression strains; (iii) characterise the phenotypes of these strains, including Ca2+ influx and cytosolic free Ca2+ homeostasis (using apoaeaquorin transformants); (iv) initiate structure-function studies on Aspergillus CCH1 with a view to understanding mechanisms of ion permeation and regulation.

Summary

unavailable

Committee	Closed Committee - Plant & Microbial Sciences (PMS)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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