BBSRC Portfolio Analyser
Award details
Regulation of stress responses in the fungal pathogen Candida albicans
Reference
P11585
Principal Investigator / Supervisor
Professor Al Brown
Co-Investigators /
Co-Supervisors
Institution
University of Aberdeen
Department
School of Medical Sciences
Funding type
Research
Value (£)
171,538
Status
Completed
Type
Research Grant
Start date
18/01/2000
End date
18/09/2002
Duration
32 months
Abstract
Candida albicans, the major fungal pathogen in humans, can evade the defences of its host to thrive in numerous hostile microenvironments. Host defence mechanisms represent stresses to the fungus, but despite the importance of stress resistance for the success of this pathogen, little is known about the regulatory pathways that control stress responses in C. albicans. In contrast, many genes involved in stress responses have been identified in the related yeast Saccharomyces cerevisiae. In this project, this information will be exploited along the C. albicans genome sequence information, to identify new genes of the stress response networks of C. albicans. Mutants that lack or overexpress these genes will be constructed and their stress-related phenotypes analysed to dissect these regulatory networks at the molecular level in this important fungal pathogen.
Summary
unavailable
Committee
Closed Committee - Plant & Microbial Sciences (PMS)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
I accept the
terms and conditions of use
(opens in new window)
export PDF file
back to list
new search