BBSRC Portfolio Analyser
Award details
Studies of expansin structure and function
Reference
P11582
Principal Investigator / Supervisor
Professor Simon McQueen-Mason
Co-Investigators /
Co-Supervisors
Institution
University of York
Department
Biology
Funding type
Research
Value (£)
208,700
Status
Completed
Type
Research Grant
Start date
01/09/1999
End date
01/09/2002
Duration
36 months
Abstract
The work will cover a number of areas related to expansin structure and function. We have recently produced active recombinant expansins in cultured insect cells, and in transgenic plants. This opens up new and important opportunities to study these unique enzymes. Using site-directed mutagenesis we will explore the role of particular residues and motifs in the binding and activity of expansins. Recently, expansin isoforms have been implicated in a number of novel biological processes. We will express expansin cDNAs from a variety of different plants and tissues and characterise the activity and substrate specificity of these isoforms. We will develop assays to determine whether expansin action involves polymer hydrolysis or hydrogen bond disruption, and whether expansin interacts with XET in the cell wall.
Summary
unavailable
Committee
Closed Committee - Plant & Microbial Sciences (PMS)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
I accept the
terms and conditions of use
(opens in new window)
export PDF file
back to list
new search