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Characterisation of conserved viral strategies for infecting insect hosts
Reference
P11541
Principal Investigator / Supervisor
Dr Julie Olszewski
Co-Investigators /
Co-Supervisors
Institution
Imperial College London
Department
Biological Sciences
Funding type
Research
Value (£)
166,180
Status
Completed
Type
Research Grant
Start date
22/11/1999
End date
22/11/2002
Duration
36 months
Abstract
GP37/fusolin and ORF145/150 related genes are found in two unrelated insect virus taxa, the baculoviruses and entomopoxviruses, suggesting they confer some broad advantage to viral pathogens utilising insect hosts. We aim to identify the function(s) of these genes as a first step towards elucidating mechanisms that are fundamental to the host/virus interaction. AcMNPV mutants lacking GP37, ORF145, ORF150 or both ORFs 145 & 150, will be characterised, and GP37 and HaEPV fusolin will be assayed for enhancing activity. Yeast 2-hybrid analysis will be used to identify proteins that interact with AcMNPV GP37, ORF145 & 150, and HaEPV fusolin & 11K protein, and antibodies raised to AcMNPV ORF145 & 150 will be used to study their expression.
Summary
unavailable
Committee
Closed Committee - Plant & Microbial Sciences (PMS)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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