Award details

Heavy metal transporting ATPases in higher plants; structure function and physiological role

Reference	P11527
Principal Investigator / Supervisor	Dr Lorraine Williams
Co-Investigators / Co-Supervisors	Professor J.L Hall
Institution	University of Southampton
Department	Centre for Biological Sciences
Funding type	Research
Value (£)	156,848
Status	Completed
Type	Research Grant
Start date	01/11/1999
End date	31/03/2003
Duration	41 months

Abstract

CPx-ATPases are a recently defined class of P-type ATPases which are thought to be important not only for the acquisition of sufficient amounts of essential heavy metal ions for normal cell functions, but also for metal ion homeostasis including heavy metal tolerance. Although homologues to bacterial and mammalian transporters exist in plants, their role in heavy metal transport is almost completely unknown. Therefore this project aims to use molecular techniques to clone the gene family members of CPx-type ATPases, to establish the specificity of these ATPases by functional studies in yeast and to investigate the physiological function by determining their tissue and cellular expression pattern. A reverse genetics approach will be taken to obtain mutant plants having disruptions in these transporters.

Summary

unavailable

Committee	Closed Committee - Plant & Microbial Sciences (PMS)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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