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The role of RNA polymerase subunit of Staphylococcus aureus

Reference	P11511
Principal Investigator / Supervisor	Professor Simon J. Foster
Co-Investigators / Co-Supervisors	Professor J Green
Institution	University of Sheffield
Department	Molecular Biology and Biotechnology
Funding type	Research
Value (£)	171,676
Status	Completed
Type	Research Grant
Start date	01/09/1999
End date	01/09/2002
Duration	36 months

Abstract

Staphylococcus aureus is a major human pathogen, an ability which is due to the production of a number of virulence determinants. We have recently identified the RNA polymerase delta subunit (RpoE) as being involved in virulence determinant production and starvation- survival. Its effects are similar to those of the well characterised virulence regulator, SarA. This suggests that these components may interact to bring about changes in gene expression. This application will analyse the role of RpoE in virulence associated, and other cellular, processes. The molecular mechanism of RpoE action will also be investigated by in vitro studies using purified components. This will allow its interaction with SarA to be determined and their combined role in the regulatory hierarchy controlling virulence determinant production to be assessed.

Summary

unavailable

Committee	Closed Committee - Plant & Microbial Sciences (PMS)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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