BBSRC Portfolio Analyser
Award details
pH signal transduction and proteolysis of the PacC transcription factor in Aspergillus nidulans
Reference
P11494
Principal Investigator / Supervisor
Emeritus Professor Herbert Arst
Co-Investigators /
Co-Supervisors
Institution
Imperial College London
Department
Dept of Medicine
Funding type
Research
Value (£)
496,212
Status
Completed
Type
Research Grant
Start date
01/06/1999
End date
01/12/2002
Duration
42 months
Abstract
Ambient pH is a major determinant in expression of numerous genes whose products function beyond the cellular permeability barrier. Previous work has shown that in Aspergillus the zinc finger transcription factor PacC activates expression of genes expressed at alkaline pH and prevents expression of genes expressed at acidic pH and that PacC is proteolytically processed to yield the functional N-terminal ~3/8 of the protein in response to a signal transduced by the palA,B,C,F,H and 1 gene products. We propose to characterise an alternative signalling pathway, obtain further information about normal pH signalling, particularly focusing on membrane components, and explore further aspects of PacC signal reception/processing and degradation.
Summary
unavailable
Committee
Closed Committee - Plant & Microbial Sciences (PMS)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
I accept the
terms and conditions of use
(opens in new window)
export PDF file
back to list
new search