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pH signal transduction and proteolysis of the PacC transcription factor in Aspergillus nidulans

ReferenceP11494
Principal Investigator / Supervisor Emeritus Professor Herbert Arst
Co-Investigators /
Co-Supervisors
Institution Imperial College London
DepartmentDept of Medicine
Funding typeResearch
Value (£) 496,212
StatusCompleted
TypeResearch Grant
Start date 01/06/1999
End date 01/12/2002
Duration42 months

Abstract

Ambient pH is a major determinant in expression of numerous genes whose products function beyond the cellular permeability barrier. Previous work has shown that in Aspergillus the zinc finger transcription factor PacC activates expression of genes expressed at alkaline pH and prevents expression of genes expressed at acidic pH and that PacC is proteolytically processed to yield the functional N-terminal ~3/8 of the protein in response to a signal transduced by the palA,B,C,F,H and 1 gene products. We propose to characterise an alternative signalling pathway, obtain further information about normal pH signalling, particularly focusing on membrane components, and explore further aspects of PacC signal reception/processing and degradation.

Summary

unavailable
Committee Closed Committee - Plant & Microbial Sciences (PMS)
Research TopicsX – not assigned to a current Research Topic
Research PriorityX – Research Priority information not available
Research Initiative X - not in an Initiative
Funding SchemeX – not Funded via a specific Funding Scheme
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