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Isolation of CARI: A gene conveying broad spectrum disease immunity

Reference	P11447
Principal Investigator / Supervisor	Professor Gary Loake
Co-Investigators / Co-Supervisors
Institution	University of Edinburgh
Department	Inst of Cell and Molecular Biology
Funding type	Research
Value (£)	159,932
Status	Completed
Type	Research Grant
Start date	01/02/2000
End date	01/02/2003
Duration	36 months

Abstract

We have identified a large number of diverse mutants perturbed in the establishment of acquired resistance. A subclass of these mutants designated car exhibit particularly high levels of immunity in the absence of spontaneous macro- or microscopic lesion formation and morphological perturbations. We will undertake a detailed characterisation of this subclass with respect to the profile of defence genes expressed and the spectrum of disease resistance established. Furthermore, we will undertake epistasis analysis with respect to nahG and npr1 for car mutants showing constitutive engagement of the SA- dependent signalling network and ein2 and coi1 for mutants exhibiting constitutive SA-independent signalling. Prior characterisation of car1, a mutant showing strikingly high levels of broad spectrum resistance in the absence of morphological perturbations highlighted the academic and commercial importance of this gene. We will isolate car1 via map based cloning.

Summary

unavailable

Committee	Closed Committee - Plant & Microbial Sciences (PMS)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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