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The biochemistry and bioenergetics of bacterial thionate respiration
Reference
P11074
Principal Investigator / Supervisor
Professor Benjamin Berks
Co-Investigators /
Co-Supervisors
Institution
University of Oxford
Department
Biochemistry
Funding type
Research
Value (£)
181,908
Status
Completed
Type
Research Grant
Start date
01/01/1999
End date
01/03/2002
Duration
38 months
Abstract
The ability to utilise sulfur compounds containing sulfur-sulfur bonds as respiratory electron acceptors is phylogenetically very widespread amongst prokaryotes. However the biochemical basis of this metabolism is poorly understood. Building on our success in an initial BBSRC-funded study we will extend our molecular understanding of tetrathionate and thiosulfate reduction in the model organism Salmonella typhimurium. In particular we aim to (i) investigate the bioenergetic organisation of thionate respiration paying particular attention to thiosulfate metabolism in which we have evidence for the involvement of both endergonic steps and obligate intraspecies hydrogen transfer and (ii) biochemically and spectroscopically characterise the reductase active sites which perform novel, molybdenum, sulfur-sulfur bond cleavage reactions.
Summary
unavailable
Committee
Closed Committee - Plant & Microbial Sciences (PMS)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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