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Cross-regulation between adhesin gene clusters in Escherichia coli
Reference
P10995
Principal Investigator / Supervisor
Professor David Gally
Co-Investigators /
Co-Supervisors
Institution
University of Edinburgh
Department
Veterinary Pathology
Funding type
Research
Value (£)
187,212
Status
Completed
Type
Research Grant
Start date
03/05/1999
End date
03/06/2002
Duration
37 months
Abstract
Bacterial adherence to specific host tissue is mediated by fimbrial and afimbrial adhesins. Many pathogenic E. coli isolates have the capacity to produce a spectrum of adhesins, but these are rarely produced at the same time. Cross-regulation between adhesin gene clusters will be characterised at the single cell level using fluorescence microscopy, fluorescence activated cell sorting (FACS) and fractionation techniques. How changes in environmental conditions impact on this regulation will also be addressed. In identified cases, genetic and biochemical approaches will be taken to understand mechanisms of cross-talk between adhesin gene clusters.
Summary
unavailable
Committee
Closed Committee - Plant & Microbial Sciences (PMS)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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