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Structural and functional characterisation of the MPG1 hydrophobin in the rice blast fungus Magnaporthe grisea
Reference
P10991
Principal Investigator / Supervisor
Professor Nicholas Talbot
Co-Investigators /
Co-Supervisors
Institution
University of Exeter
Department
Biosciences
Funding type
Research
Value (£)
233,928
Status
Completed
Type
Research Grant
Start date
01/03/1999
End date
01/03/2002
Duration
36 months
Abstract
The MPG1 gene encodes a fungal hydrophobin which is required to for full pathogenicity of the rice blast fungus Magnaporthe grisea. The MPG1 hydrophobin is involved in leaf surface perception and acts as a morphogenetic determinant of appressorium development. In this project we aim to determine structural features of MPG1 required for surface perception and hydrophobin aggregation by using heterologous hydrophobin complementation, mutagenesis and expression studies. We will then investigate how MPG1 secretion triggers the cAMP- dependent signal transduction pathway for appressorium formation by direct measurement of intracellular cAMP is isogenic wild type and delta mpg1 mutants and analysis of a series of signalling mutants. We also aim to identify MPG1-interacting factors which may allow attachment of the hydrophobin layer to the underlying cell wall during appressorium formation.
Summary
unavailable
Committee
Closed Committee - Plant & Microbial Sciences (PMS)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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