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Iron regulation in Escherichia coli

Reference	P10982
Principal Investigator / Supervisor	Professor Simon C Andrews
Co-Investigators / Co-Supervisors
Institution	University of Reading
Department	Animal and Microbial Sciences
Funding type	Research
Value (£)	179,236
Status	Completed
Type	Research Grant
Start date	01/05/1999
End date	01/05/2002
Duration	36 months

Abstract

Our previous work shows, contrary to expectation, that fur mutants are iron deficient and lack the major iron proteins (such as bacterioferritin [Bfr] and ferritin [FtnA] of fur+ strains. This new function for Fur in induction of iron proteins and regulating cellular iron demand will be investigated by studying the mechanism of Fe2+ -Fur dependent induction of bfr and ftnA gene expression. The function of a newly discovered ferritin gene (ftnB) will be investigated, as will iron release and uptake from iron-storage proteins in vivo. The role of the sigma S- regulated Bfr during slow growth will be assessed through competition experiments with marked in-phase bfr mutants, and the function of the Fur-repressed, NIFU-like [2Fe-2S] Bfr- associated ferredoxin (BfD) in iron release/delivery and iron-sulphur cluster formation will be studied.

Summary

unavailable

Committee	Closed Committee - Plant & Microbial Sciences (PMS)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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