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The role of ppGpp as an intracellular signalling molecule for the initiation of antibiotic production of Streptomyces coelicolor A3(2)
Reference
P10950
Principal Investigator / Supervisor
Professor Keith Chater
Co-Investigators /
Co-Supervisors
Institution
John Innes Centre
Department
John Innes Centre Department
Funding type
Research
Value (£)
186,979
Status
Completed
Type
Research Grant
Start date
04/10/1999
End date
04/10/2002
Duration
36 months
Abstract
Antibiotic production in Streptomyces generally occurs in a growth phase-dependent manner, and in liquid culture is usually confined to stationary phase. Under conditions of nitrogen- limitation, the stationary phase production of the antibiotics actinorhodin and undecylprodigiosin by Streptomyces coelicolor A3(2) requires relA-dependent ppGpp synthesis, but under conditions of phosphate- or carbon-starvation, relA is not needed. This proposal aims to elucidate the role of ppGpp synthesis in activating antibiotic production in S. coelicolor under conditions of phosphate- or carbon-limitation, to assess relA-independent mechanisms of ppGpp synthesis, and to analyse the mechanism where ppGpp activates gene transcription under conditions of nitrogen limitation
Summary
unavailable
Committee
Closed Committee - Plant & Microbial Sciences (PMS)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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