BBSRC Portfolio Analyser
Award details
Coordination of responses to morphogenesis and amino acid starvation in the fungal pathogen Candida albicans
Reference
P10256
Principal Investigator / Supervisor
Professor Al Brown
Co-Investigators /
Co-Supervisors
Institution
University of Aberdeen
Department
School of Medical Sciences
Funding type
Research
Value (£)
192,991
Status
Completed
Type
Research Grant
Start date
01/03/1999
End date
01/04/2002
Duration
37 months
Abstract
Yeast-to-hyphal morphogenesis can be triggered by amino acid starvation in Candida albicans, reflecting the integration of metabolic and cellular responses to a specific stress in this fungal pathogen. This project will define the role of CaGcn4p in the transcriptional activation of amino acid biosynthetic genes and the extent to which this regulator co-ordinates the morphogenetic response to amino acid starvation in C. albicans. CaGCN4 gene regulation will be defined under these conditions, sequence- specific transcriptional activation by CaGen4p will be analysed, the effects of CaGCN4 mutations upon the amino acid starvation response and morphogenesis will be established, and the influence of well-defined morphogenetic mutations upon CaGCN4 regulation and the amino acid starvation response will be characterised.
Summary
unavailable
Committee
Closed Committee - Plant & Microbial Sciences (PMS)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
I accept the
terms and conditions of use
(opens in new window)
export PDF file
back to list
new search