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Shape and form in microbial cells: the structural basis for cell division in trypanosomes
Reference
P10244
Principal Investigator / Supervisor
Professor Keith Gull
Co-Investigators /
Co-Supervisors
Institution
The University of Manchester
Department
Life Sciences
Funding type
Research
Value (£)
171,641
Status
Completed
Type
Research Grant
Start date
01/08/1998
End date
31/01/2002
Duration
42 months
Abstract
The Trypanosoma brucei cell possesses a single flagellum attached to the cell body through a specific filament system called the Flagellum Attachment zone (FAZ). This single complex of filaments is duplicated in the cell cycle along with the new flagellum and appears as a possible positional indicator for defining the cell polarity and the plane of cytokinesis. The aims of this project are first to obtain complete sequence information and genomic characterisation of the gene encoding the major polypeptide of the filament. We will then study the expression of the FAZ polypeptides and their assembly in vivo and in vitro into filaments, and test the hypothesis that this filament is the major spatial organiser of the cell by functional analysis of mutants generated using a variety of reverse genetic approaches now available in trypanosomes.
Summary
unavailable
Committee
Closed Committee - Plant & Microbial Sciences (PMS)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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