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The molecular mechanism of carotenogenesis: a light-induced light-protective response in Myxococcus xanthus
Reference
P10242
Principal Investigator / Supervisor
Professor David Hodgson
Co-Investigators /
Co-Supervisors
Institution
University of Warwick
Department
Biological Sciences
Funding type
Research
Value (£)
193,836
Status
Completed
Type
Research Grant
Start date
22/03/1999
End date
22/03/2002
Duration
36 months
Abstract
Carotenogenesis is a light-induced, light-protective response in Myxococcus xanthus. Light induction is controlled by the carQRS operon. The objectives of the research are to prove physical interactions between CarQ, a sigma factor, and CarR, a membrane- bound anti-sigma factor and CarS, an anti-repressor, and the CarA complex, a repressor. We will use two approaches: the yeast two- hybrid system and genetics. We will use localised and site- directed mutagenesis to isolate mutant forms of CarR that cannot bind CarQ and visa versa. We will isolate suppresser mutations in the other gene that will allow binding again. We will obtain high level expression of native CarS for structural studies and probe the role of the C-terminus of CarS.
Summary
unavailable
Committee
Closed Committee - Plant & Microbial Sciences (PMS)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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