Award details

The architecture of a unique electron transfer chain in Shewanella

Reference	P10209
Principal Investigator / Supervisor	Professor Graeme Reid
Co-Investigators / Co-Supervisors	Professor Stephen Chapman
Institution	University of Edinburgh
Department	Inst of Cell and Molecular Biology
Funding type	Research
Value (£)	202,979
Status	Completed
Type	Research Grant
Start date	01/10/1998
End date	01/10/2001
Duration	36 months

Abstract

Shewanella species are important organisms in food spoilage and in the biogeochemical cycling of iron. Their remarkable diversity of anaerobic metabolism is a key element in both areas and this proposal seeks to identify the roles of key electron transfer proteins in the anaerobic respiration in this organism. The soluble, periplasmic fumarate reductase is unique among known bacterial proteins. We shall specifically test the proposed role of a membrane bound tetraheme cytochrome c (a NapC homologue) as the physiological electron donor to the fumarate reductase (and to other terminal reductases) by constructing and characterising a gene knockout. Physiological experiments will be complemented by biochemical analysis of the isolated proteins and their interactions. The roles of small periplasmic cytochromes c3 and c5 will be identified using similar approaches.

Summary

unavailable

Committee	Closed Committee - Plant & Microbial Sciences (PMS)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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